Clinical Neurotoxicology: Syndromes, Substances, Environments

Clinical Neurotoxicology offers accurate, relevant, and comprehensive coverage of a field that has grown tremendously in the last 20 years. You'll get a current symptomatic approach to treating disorders caused by neurotoxic agents, environmental factors-such as heavy metals and pesticides-and more. Apply discussions of cellular and molecular processes and pathology to clinical neurology. Leading authorities and up-and-coming clinical neurotoxicologists present their expertise on wide-ranging, global subjects and debate controversies in the specialty, including Gulf War Syndrome. And, Expert Consult functionality allows you to access the full text of the book online, from any Internet connection.

* Provides a complete listing of neurotoxic agents-from manufactured to environmental-so you get comprehensive, clinical coverage.

* Covers how toxins manifest themselves according to age and co-morbidity so that you can address the needs of all your patients.

* Offers broad and in-depth coverage of toxins from all over the world through contributions by leading authorities and up-and-coming clinical neurotoxicologists.

* Features discussion of controversial and unusual topics such as Gulf War Syndrome, Parkinson's Disease, motor neuron disease, as well as other issues that are still in question.

* Includes access to www.expertconsult.com, a companion website where you can quickly search the complete contents of the book.

Hardcover: 720 pages
Publisher: Saunders; Har/Psc edition (June 18, 2009)
Language: English
ISBN-10: 0323052606
ISBN-13: 978-0323052603
Product Dimensions: 11.1 x 8.7 x 1.3 inches

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Management Strategies in Antithrombotic Therapy

Intravascular thrombus formation remains one of the most significant problems in cardiovascular medicine. It underlies the clinical presentation of acute coronary syndromes, including unstable angina and non-ST-segment elevation myocardial infarction (NSTEMI) and ST-segment elevation myocardial infarction.

More and more individuals are stricken with an acute MI and undergo a percutaneous coronary intervention (PCI). Several reasons apply, including an increasingly aged population, the growing burden of chronic risk factors such as diabetes, obesity, sedentary behaviour, and improvements in early recognition and intervention. Thrombus formation also results in substantial morbidity and mortality. Despite significant advances in prevention and treatment of venous thromboembolism, pulmonary embolism remains a common preventable cause of hospital deaths. Implementing the most appropriate, and safe, anticoagulation therapy across the spectrum of cardiovascular disease in the presence of a wide range of other risk factors remains a challenge.

Written by leading authorities in the field, Management Strategies in Antithrombotic Therapy offers a comprehensive review of antithrombotic therapy, including the latest therapies, risk factors and evidence-based strategy. The book acquaints readers with the data behind the commonly used antithrombotic agents and assists them in formulating a sound, evidence-based therapeutic strategy appropriate for each patient.

This book is an invaluable resource for all postgraduate students and specialist physicians in cardiovascular medicine, cardiac and vascular surgery, and critical care.

Hardcover: 366 pages
Publisher: Wiley-Interscience; 1 edition (January 9, 2008)
Language: English
ISBN-10: 0470319380
ISBN-13: 978-0470319383
Product Dimensions: 9.8 x 6.7 x 1 inches

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Fibrinolytic and Antithrombotic Therapy: Theory, Practice, and Management

Thrombotic disorders of the circulatory system represent the leading cause of morbidity, motality, and health care expenditure in the United States. Fibrinolytic and Antithrombotic Therapy provides a practical, evidence-based approach to the management of thrombotic disorders for all clinicians involved in the care of patients with these disorders. It provides not only vital conceptual information on fibrinolytic and antithrombotic therapy, but also the means to apply it to everyday decision making and patient care. Focusing on managment guidelines and critical pathways, the text stresses practicality and usability. It will be a valuable resource for the wide range of clinicians involved in the care of patients with these disorders, including cardiologists, emergency physicians, primary care physicians, hematologists, neurologists, intensivists, pharmacists, and nurse practitioners.

The Second Edition of Fibrinolytic and Antithrombotic Therapy, even more concise and clinically relevant than the First, provides vital, evidence-based information on management of patients with arterial and venous thrombotic disorders. Since the First Edition, the text has been expanded to cover the evolving topics of atherothrombosis, thrombocardiology, hematologic/thrombophilic conditions, and vascular medicine. It includes up-to-date guidelines for antithrombotic and fibrinolytic therapy, and offers concise summaries of current "standards of care." Chapters are dedicated to discussions of patient-specific therapeutics and to the importance of genomics, proteomics, and metabolomics in defining genotype-phenotype relationships, while throughout the book coagulation, inflammation, and vascular medicine are newly examined as elements in an intricatley-linked triad of biochemical and cellular based phenomenology.

Paperback: 424 pages
Publisher: Oxford University Press, USA; 2 edition (March 23, 2006)
Language: English
ISBN-10: 0195155645
ISBN-13: 978-0195155648
Product Dimensions: 8.2 x 5.5 x 0.9 inches

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Neuroanatomy: An Atlas of Structures, Sections, and Systems

The Sixth Edition of Dr. Haines’s best-selling neuroanatomy atlas features a stronger clinical emphasis, with significantly expanded clinical information and correlations. More than 110 new images-including MRI, CT, MR angiography, color line drawings, and brain specimens-highlight anatomical-clinical correlations.

Internal spinal cord and brainstem morphology are presented in a new format that shows images in both anatomical and clinical orientations, correlating this anatomy exactly with how the brain and its functional systems are viewed in the clinical setting. A new chapter contains over 235 USMLE-style questions, with explained answers.

Paperback: 319 pages
Publisher: Lippincott Williams & Wilkins; Sixth Edition edition (October 1, 2003)
Language: English
ISBN-10: 0781746779
ISBN-13: 978-0781746779
Product Dimensions: 11.8 x 9 x 0.6 inches

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Atlas of the Diabetic Foot

Foot ulcers occur in approximately 15% of the patients with diabetes mellitus in their lifetime, with a major impact on their quality of life. Many hospital admissions related to diabetes are due to foot ulcers, which can result in prolonged hospital stay and increased morbidity and mortality. The majority of lower limb amputations are performed in patients with diabetes every year (80,000 at least in the USA). Most of the diabetes-related foot problems can be prevented or their severity reduced by early detection and treatment. This book contributes to improved foot care through raised awareness of prevention, clinical manifestations, diagnosis and management among healthcare professionals.

This comprehensive atlas, now in a second edition, provides:

* 520 colour photographs, graphs, tables and imaging studies

* Educational examples taken from genuine case reports

* A reference guide for identifying patients at risk for foot problems

* Illustration of common problems such as neuropathic and neuroischaemic ulcers, ischaemia and infection

* Introduction to new technologies and bioengineered materials used for the treatment of foot ulcers

This book will be of interest to diabetologists, endocrinologists, podiatrists, specialist nurses, general practitioners, surgeons and clinical researchers.

Hardcover: 260 pages
Publisher: Wiley-Blackwell; 2 edition (May 10, 2010)
Language: English
ISBN-10: 1405191791
ISBN-13: 978-1405191791
Product Dimensions: 9.8 x 7.3 x 0.8 inches

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Neurology and Clinical Neuroscience

This brand-new text provides you with an easy-to-use, comprehensive reference that features a clinical perspective balanced with relevant basic science. Inside, you'll find discussions of the latest research and how it has led to a greater understanding of the cause of disease, as well as burgeoning tests and the latest therapeutic agents available. From Alzheimer's disease to vestibular system disorders, you'll find the practical guidance you need to diagnose effectively and provide an appropriate therapeutic approach for each individual case. Plus, a templated, four-color design offers you easy access to pertinent information

Integrates basic science with clinical neurology to help you better understand neurologic diseases and provide the most accurate diagnosis and best treatment plan for each patient.

Discusses the latest research results and offers new information on treatment options. Features the expertise of international authorities, providing a worldwide perspective.

Hardcover: 1664 pages
Publisher: Mosby (December 18, 2006)
Language: English
ISBN-10: 0323033547
ISBN-13: 978-0323033541
Product Dimensions: 11.2 x 8.7 x 2.5 inches

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Headache (Cambridge Pocket Clinicians)

Headache is the most common presenting symptom in neurology and constitutes more than one-third of primary care consultations. Organized according to the presenting features of the headache (acute, episodic and chronic), this handbook provides diagnostic and treatment information for both common and uncommon causes of headache. Making maximum use of lists, bullet points, summary boxes and illustrations, it allows the reader fast access to essential information where it is needed most. Each topic is dealt with succinctly, using up-to-date knowledge and experience of the authors, all of whom are headache experts from leading clinical centers in the USA and Canada. Providing comprehensive and detailed coverage to satisfy the needs of the busy neurologist, residents in neurology, neurosurgery, psychiatry and other fields of internal medicine, this book will also be a valuable guide to practising clinicians who do not deal with headache on a regular basis.

Mass Market Paperback: 256 pages
Publisher: Cambridge University Press; 1 edition (April 30, 2010)
Language: English
ISBN-10: 0521720575
ISBN-13: 978-0521720571
Product Dimensions: 6.8 x 4.2 x 0.8 inches

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Atlas of Sleep Medicine

This comprehensive atlas of tracings of polysomnographic studies covers the technical aspects of conducting studies, and includes the features of the various adult and pediatric sleep disorders. Comprehensive and contemporary atlas. Discusses the significance of findings and their correlation with the clinical presentation of the patient. Authoritative and well-organized.

Hardcover: 376 pages
Publisher: Butterworth-Heinemann; 1 edition (June 1, 2005)
Language: English
ISBN-10: 0750673982
ISBN-13: 978-0750673983
Product Dimensions: 11 x 8.7 x 0.9 inches

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Diagnostic Neuroradiology

In this monograph, the authors summarize their findings in complex neuroimaging work (cranio-, spondylo-, myelo- and angiography as well as CT and MR imaging of the brain and spine) during their longstanding experience at the N. Burdenko Neurosurgical Institute in Moscow. The book begins with a review of modern neuroimaging techniques: CT and MR angiography, perfusion and diffusion imaging, tractography, spectroscopy and functional MR imaging.

The problems and various other aspects of diagnosis of intra- and extra-axial brain tumors (more than 30,000 verified cases) as well as of cerebrovascular, infectious, demyelinating, degenerative and traumatic brain and spine lesions are discussed. The volume is well illustrated with angiographic, CT and MR images of complex diagnostic studies. The numerous images represent a "visual text," which can be used as an atlas by practical clinicians.

This book is a comprehensive reference manual for neurologists, neurotraumatologists and radiologists. It may also be of interest to technicians, medical physicists, students and other specialists interested in neurovisualization and diagnostic imaging.

Hardcover: 1288 pages
Publisher: Springer; 1 edition (February 13, 2009)
Language: English
ISBN-10: 3540756523
ISBN-13: 978-3540756521
Product Dimensions: 11.6 x 9.1 x 2.4 inches

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Neurology Board Review: An Illustrated Study Guide

Preparing the reader for the written portion of the Neurology Board examination and the Residency In-Service Training Examination (RITE) of the American Academy of Neurology, this reference provides a comprehensive review of the most critical topics in neurology.  With the abundance of neuropathology and neuroimaging figures and neuroanatomy and neurophysiology illustrations, readers will not need to refer to multiple sources for a comprehensive review to prepare for the Neurology Boards and in-service examination.

Hardcover: 1024 pages
Publisher: Informa Healthcare; 1 edition (April 11, 2007)
Language: English
ISBN-10: 0849337917
ISBN-13: 978-0849337918
Product Dimensions: 10.9 x 8.4 x 1.8 inches

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Physiology and Pathology of chloride transporters and channels in the nervous system: From molecules to diseases

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases.

* The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years

* Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control.

* The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation.

* Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases.

* Involves all of the leading researchers in the field.

* Includes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field.

Hardcover: 500 pages
Publisher: Academic Press; 1 edition (September 11, 2009)
Language: English
ISBN-10: 0123743737
ISBN-13: 978-0123743732
Product Dimensions: 11.2 x 8.7 x 1.6 inches

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Neurocritical Care: A Guide to Practical Management (Competency-Based Critical Care)

Traumatic brain injury is the leading cause of death in young people in the UK and USA. The vast majority of these patients will be initially managed outside the teaching hospital environment and many will remain there for the duration of their treatment. As clinicians, what happens during the first hours and days after injury can have a huge influence on the patient’s chance of survival and also their quality of life after the injury.

Results of a recent national survey have highlighted 2 main areas of major concern. Firstly, there are far too few specialist neurosurgical beds in out tertiary referral centers, which means that District General Hospital Intensive Care Units are frequently having to manage very seriously brain injured patients. Secondly, many clinicians do not know when they should be speaking to their Regional Neurosurgical Centre, do not fully understand how they should be managing these patients, do not know how to interpret the relevant physiological and radiological data, and have difficulty identifying when to escalate treatment and when the situation has become futile.

Lives could therefore be saved and outcomes improved with the introduction of common treatment pathways and better defined lines of communication between referring hospitals and specialist centers.

Paperback: 177 pages
Publisher: Springer; 1st Edition. edition (February 18, 2010)
Language: English
ISBN-10: 1848820690
ISBN-13: 978-1848820692
Product Dimensions: 9.9 x 6.8 x 0.4 inches

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Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms

This book is the result of a convergence of scientific information regarding mechanisms that produce acute nerve cell death in the brain. Although seemingly disparate, stroke, brain and spinal cord trauma, coma from a low serum glucose concentration (hypoglycemia), and prolonged epileptic seizures have in common the inciting factor of excitotoxicity, the activation of a specific subtype of glutamate receptor by an elevated extracellular glutamate concentration that results in an excessive influx of calcium into nerve cells. The high calcium concentration in nerve cells activates several enzymes that are responsible for degradation of cytoplasmic proteins and cleavage of nuclear DNA, resulting in nerve cell death. The high calcium concentration also interferes with mitochondrial respiration, with the resultant production of free radicals that damage cellular membranes and nuclear DNA. Understanding the biochemical pathways that produce nerve cell death is the first step toward devising an effective neuroprotective strategy, the ultimate goal.

Acute Neuronal Injury will be useful to neuroscientists and general cell biologists interested in cell death. The book will also be helpful to clinically oriented neuroscientists, including neurologists, neurosurgeons and psychiatrists.

Hardcover: 306 pages
Publisher: Springer; 1st Edition. edition (November 18, 2009)
Language: English
ISBN-10: 038773225X
ISBN-13: 978-0387732251
Product Dimensions: 9.2 x 6.2 x 1 inches

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Cerebellar Disorders: A Practical Approach to Diagnosis and Management

During the last three decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and the biology of mental processes, behavioral symptoms and emotion. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias, and the growing number of diseases presents a source of difficulty for clinicians during daily practice. This practical guide summarizes and evaluates current knowledge in the field of cerebellar disorders. Encompassing details of both common and uncommon cerebellar ataxias, including vascular, immune, neoplastic, infectious, traumatic, toxic and inherited disorders, this book will assist clinicians in the diagnosis and management of the full spectrum of cerebellar ataxias encountered in daily practice. Essential reading for clinicians, including general practitioners, neurologists, pediatricians, radiologists, psychiatrists and neuropsychologists, this will also prove a valuable tool for students, trainees and researchers.

This practical guide summarizes and evaluates current knowledge in the field of cerebellar disorders. Encompassing details of both common and uncommon cerebellar ataxias, including vascular, immune, neoplastic, infectious, traumatic, toxic and inherited disorders, this book will assist clinicians in the diagnosis and management of the full spectrum of cerebellar ataxias.

Hardcover: 312 pages
Publisher: Cambridge University Press; 1 edition (April 30, 2010)
Language: English
ISBN-10: 0521878136
ISBN-13: 978-0521878135
Product Dimensions: 9.8 x 7.4 x 0.9 inches

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Abram's ANGIOGRAPHY INTERVENTIONAL RADIOLOGY, Second Edition

The Interventional Radiology volume of the landmark reference Abrams' Angiography has now been expanded and thoroughly revised to reflect dynamic advances in interventional radiology. More than 60 contributors representing a "Who's Who" of the specialty provide comprehensive, step-by-step coverage of all contemporary vascular and nonvascular interventional procedures. Major sections discuss today's equipment and describe interventions for specific disorders of each organ system, as well as for trauma, pediatric diseases, abscess drainage, and miscellaneous disorders. Fifteen new chapters cover cutting-edge innovations, including stent-grafts, radiofrequency ablation, CT angiography, MR angiography, uterine fibroid embolization, and vertebroplasty. More than 1,100 illustrations complement the text.

Hardcover: 1344 pages.
Publisher: Lippincott Williams & Wilkins; Second Edition (September 1, 2005).
Language: English.
ISBN-10: 0781740894.
ISBN-13: 978-0781740890.
Product Dimensions: 11 x 8.8 x 2.1 inches

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